Tetanus is a vaccine-preventable disease caused by a toxin produced by the bacteria Clostridium tetani. Tetanus spores are found in soil throughout the world. The disease is acquired when material containing these spores contaminates a wound. The toxin released from the bacteria may then attack the nerves of the brain and spinal cord. Tetanus-prone wounds include the following:
damaged tissue and deep puncture wounds where there has been contact with soil or manure
wounds containing foreign bodies
bone fractures where the skin is broken
wounds or burns in patients who have infection of the bloodstream
Tetanus occurs worldwide, but is more common in resource-poor countries where vaccination coverage is low.
Generalised tetanus accounts for most cases worldwide; this is associated with intense painful contraction and spasm of the skeletal muscles. It commonly presents with trismus (also known as lockjaw), characterised by spasm of the facial muscles. Other effects of these muscle spasms include: stiffness of the neck, forceful arching of the back, abnormal breathing patterns and difficulty swallowing. With intensive medical support, death from tetanus occurs in 10 to 20 percent of cases.